RHE-LC / Human Epidermal Model Langerhans cells
Description
The SkinEthic™ RHE-LC model is a standard epidermal model in which Langerhans cells progenitors have been integrated. During the tissue reconstruction, these immature cells have differentiated into antigen-presenting Langerhans cells expressing the specific marker CD207 (langerin). They are mostly located and evenly spread within the supra-basal epidermal layer.
The SkinEthic™ RHE-LC model is therefore expected to be a useful tool for skin immune response studies.
Specific markers
Langerhans cells markers :
Differentiation markers:
- Filaggrin
- Involucrin
- Loricrin
- Keratin 10
- Keratin 5
- Presence of different epidermal classes of lipids comprising ceramides
Dermal-Epidermal junction markers
- Type IV collagen
- Laminin V
- Alpha6Beta4-integrin
- BP antigen
Proliferation markers
in vitro