Back In vitro test approach

AUTHORS : Detroyer A. Meunier Jean-Roch Note R. Prunier B. Rathman J.F. RINGEISEN Stephanie Schwab C.H. Yang C.

MODELS : EPISKIN RHE / RECONSTRUCTED HUMAN EPIDERMIS

APPLICATIONS : SKIN IRRITATION OF CHEMICALS

2011
L'Oreal

A mechanistic rationale for the prediction of skin irritancy effects implemented in a workflow process

As part of the development of alternatives to animal testing, a workflow algorithm wasdeveloped to predict a molecule’s potential to trigger skin irritancy (SI) based on in vivoDraize legacy data (OECD TG404). A key requirement from safety evaluators was thepossibility to distinguish irritants from non irritants but also to predict the severity of effects.The workflow was developed for diverse chemical classes using a training set of chemicalsrepresentative of the cosmetic industry portfolio.