EpiSkin / Human Epidermis

Name

EpiSkin^TM Small or Large / Reconstructed Human Epidermis

Description

EpiSkin^TM is an in vitro reconstructed human epidermis from normal human keratinocytes cultured on a collagen matrix at the air-liquid interface. This model exists at different stages of maturity.

This model is histologically similar to the in vivo human epidermis.

Specific markers

Differentiation markers:

Filaggrin
Involucrin
Loricrin
Keratin 10
Keratin 5
Presence of different epidermal classes of lipids comprising ceramides

Dermal-Epidermal junction markers

Type IV collagen
Laminin V
Alpha6Beta4-integrin
BP antigen

Proliferation markers

Ki67

Applications

Skin irritation
Skin corrosion
UV Exposure
DNA Damage
Bacterial adhesion
Omics
Permeability

Format

0.38 cm² (EpiSkin^TMSmall Model) (See picture)
1.07 cm² (EpiSkin ^TMLarge Model) (See picture)