PROMISING ALTERNATIVE METHOD FOR SKIN PENETRATION EVALUATION USING RECONSTRUCTED EPIDERMIS MODEL

Measurement of dermal bioavailability is necessary to evaluate the exposure andto estimate the risk associated with a cosmetic ingredient applied on the skin. Forsuch study, its use is time consuming and requires numerous replicates due to the variability ofthe donors.Reconstructed skin models have had a great development over the last tenyears. The Episkin(www.skinethic.com), highly reproducible, available in multi-wells, and directly usefulin its insert. It is an ex vivo human skin is the tool recommended by regulators. However,® model has the advantages to be commercially availablein vitro human epidermis equivalent model with histologicalprofile and metabolic capabilities similar to the human skin.